Axillary Metastasis of Malignant Melanoma Mimicking a Breast Carcinoma
Identifieur interne : 008527 ( Main/Exploration ); précédent : 008526; suivant : 008528Axillary Metastasis of Malignant Melanoma Mimicking a Breast Carcinoma
Auteurs : A. Andea [États-Unis] ; E. Satter [États-Unis] ; J. R. Mcevoy [États-Unis] ; K. Williams [États-Unis] ; K. Mikhitarian [États-Unis] ; J. Metcalf [États-Unis]Source :
- Journal of Cutaneous Pathology [ 0303-6987 ] ; 2005-01.
Abstract
We describe here the case of a female patient with an otherwise classic invasive melanoma of the upper extremity, demonstrating the typical immunohistochemical profile, who presented three years later with massive ipsilateral axillary node metastases. The metastatic tumor had morphologic features similar to the primary melanoma, however at immunohistochemical level the tumor cells not only gained expression of pan‐cytokeratin (AE1/AE3) but also lost expression of all standard melanoma markers (S100, Melan‐A, HMB‐45, MIT‐1, and tyrosinase) thus mimicking a poorly differentiated mammary carcinoma. Additional stains reveal expression of Vimentin, NSE, c‐kit, CD10 and negativity for CK7, CK20, BR2, ER/PR, mucin, and LCA. To rule out a breast carcinoma, real‐time RT‐PCR was performed on a lymph node using six breast cancer‐associated genes (>99% sensitivity), which was also negative. Clinical work‐up of the patient failed to reveal abnormal masses in the breast or elsewhere. The clinical history, histological appearance, immunohistochemical profile (including negative CK7 and positive NSE, c‐kit and CD10) as well as a negative RT‐PCR renders almost null the possibility of a breast carcinoma and supports a diagnostic of melanoma in this case. Cases like ours may be easily misclassified unless a concerted approach is used to reach the correct diagnosis.
Url:
DOI: 10.1111/j.0303-6987.2005.0320i.x
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 006F23
- to stream Istex, to step Curation: 006F23
- to stream Istex, to step Checkpoint: 001D03
- to stream Main, to step Merge: 008750
- to stream Main, to step Curation: 008527
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Axillary Metastasis of Malignant Melanoma Mimicking a Breast Carcinoma</title><author><name sortKey="Andea, A" sort="Andea, A" uniqKey="Andea A" first="A." last="Andea">A. Andea</name></author><author><name sortKey="Satter, E" sort="Satter, E" uniqKey="Satter E" first="E." last="Satter">E. Satter</name></author><author><name sortKey="Mcevoy, J R" sort="Mcevoy, J R" uniqKey="Mcevoy J" first="J. R." last="Mcevoy">J. R. Mcevoy</name></author><author><name sortKey="Williams, K" sort="Williams, K" uniqKey="Williams K" first="K." last="Williams">K. Williams</name></author><author><name sortKey="Mikhitarian, K" sort="Mikhitarian, K" uniqKey="Mikhitarian K" first="K." last="Mikhitarian">K. Mikhitarian</name></author><author><name sortKey="Metcalf, J" sort="Metcalf, J" uniqKey="Metcalf J" first="J." last="Metcalf">J. Metcalf</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:ED01D07364B3D36C0BE29001C4819653F7E26DF0</idno><date when="2005" year="2005">2005</date><idno type="doi">10.1111/j.0303-6987.2005.0320i.x</idno><idno type="url">https://api.istex.fr/document/ED01D07364B3D36C0BE29001C4819653F7E26DF0/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">006F23</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">006F23</idno><idno type="wicri:Area/Istex/Curation">006F23</idno><idno type="wicri:Area/Istex/Checkpoint">001D03</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001D03</idno><idno type="wicri:doubleKey">0303-6987:2005:Andea A:axillary:metastasis:of</idno><idno type="wicri:Area/Main/Merge">008750</idno><idno type="wicri:Area/Main/Curation">008527</idno><idno type="wicri:Area/Main/Exploration">008527</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">Axillary Metastasis of Malignant Melanoma Mimicking a Breast Carcinoma</title><author><name sortKey="Andea, A" sort="Andea, A" uniqKey="Andea A" first="A." last="Andea">A. Andea</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Medical University of South Carolina, Charleston, SC</wicri:regionArea><placeName><region type="state">Caroline du Sud</region></placeName></affiliation></author><author><name sortKey="Satter, E" sort="Satter, E" uniqKey="Satter E" first="E." last="Satter">E. Satter</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Medical University of South Carolina, Charleston, SC</wicri:regionArea><placeName><region type="state">Caroline du Sud</region></placeName></affiliation></author><author><name sortKey="Mcevoy, J R" sort="Mcevoy, J R" uniqKey="Mcevoy J" first="J. R." last="Mcevoy">J. R. Mcevoy</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Medical University of South Carolina, Charleston, SC</wicri:regionArea><placeName><region type="state">Caroline du Sud</region></placeName></affiliation></author><author><name sortKey="Williams, K" sort="Williams, K" uniqKey="Williams K" first="K." last="Williams">K. Williams</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Medical University of South Carolina, Charleston, SC</wicri:regionArea><placeName><region type="state">Caroline du Sud</region></placeName></affiliation></author><author><name sortKey="Mikhitarian, K" sort="Mikhitarian, K" uniqKey="Mikhitarian K" first="K." last="Mikhitarian">K. Mikhitarian</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Medical University of South Carolina, Charleston, SC</wicri:regionArea><placeName><region type="state">Caroline du Sud</region></placeName></affiliation></author><author><name sortKey="Metcalf, J" sort="Metcalf, J" uniqKey="Metcalf J" first="J." last="Metcalf">J. Metcalf</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Medical University of South Carolina, Charleston, SC</wicri:regionArea><placeName><region type="state">Caroline du Sud</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Cutaneous Pathology</title><title level="j" type="alt">JOURNAL OF CUTANEOUS PATHOLOGY</title><idno type="ISSN">0303-6987</idno><idno type="eISSN">1600-0560</idno><imprint><biblScope unit="vol">32</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="73">73</biblScope><biblScope unit="page" to="73">73</biblScope><biblScope unit="page-count">1</biblScope><publisher>Blackwell Publishing Ltd/Inc.</publisher><pubPlace>Oxford, UK; Malden, USA</pubPlace><date type="published" when="2005-01">2005-01</date></imprint><idno type="ISSN">0303-6987</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0303-6987</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We describe here the case of a female patient with an otherwise classic invasive melanoma of the upper extremity, demonstrating the typical immunohistochemical profile, who presented three years later with massive ipsilateral axillary node metastases. The metastatic tumor had morphologic features similar to the primary melanoma, however at immunohistochemical level the tumor cells not only gained expression of pan‐cytokeratin (AE1/AE3) but also lost expression of all standard melanoma markers (S100, Melan‐A, HMB‐45, MIT‐1, and tyrosinase) thus mimicking a poorly differentiated mammary carcinoma. Additional stains reveal expression of Vimentin, NSE, c‐kit, CD10 and negativity for CK7, CK20, BR2, ER/PR, mucin, and LCA. To rule out a breast carcinoma, real‐time RT‐PCR was performed on a lymph node using six breast cancer‐associated genes (>99% sensitivity), which was also negative. Clinical work‐up of the patient failed to reveal abnormal masses in the breast or elsewhere. The clinical history, histological appearance, immunohistochemical profile (including negative CK7 and positive NSE, c‐kit and CD10) as well as a negative RT‐PCR renders almost null the possibility of a breast carcinoma and supports a diagnostic of melanoma in this case. Cases like ours may be easily misclassified unless a concerted approach is used to reach the correct diagnosis.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Caroline du Sud</li></region></list><tree><country name="États-Unis"><region name="Caroline du Sud"><name sortKey="Andea, A" sort="Andea, A" uniqKey="Andea A" first="A." last="Andea">A. Andea</name></region><name sortKey="Mcevoy, J R" sort="Mcevoy, J R" uniqKey="Mcevoy J" first="J. R." last="Mcevoy">J. R. Mcevoy</name><name sortKey="Metcalf, J" sort="Metcalf, J" uniqKey="Metcalf J" first="J." last="Metcalf">J. Metcalf</name><name sortKey="Mikhitarian, K" sort="Mikhitarian, K" uniqKey="Mikhitarian K" first="K." last="Mikhitarian">K. Mikhitarian</name><name sortKey="Satter, E" sort="Satter, E" uniqKey="Satter E" first="E." last="Satter">E. Satter</name><name sortKey="Williams, K" sort="Williams, K" uniqKey="Williams K" first="K." last="Williams">K. Williams</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 008527 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 008527 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:ED01D07364B3D36C0BE29001C4819653F7E26DF0
|texte= Axillary Metastasis of Malignant Melanoma Mimicking a Breast Carcinoma
}}
| This area was generated with Dilib version V0.6.31. |  |